【摘要】 目的　探讨慢型克山病患者血清Ⅰ型前胶原羧基末端肽 (PⅠCP)浓度的变化。方法　用ELISA方法测定了观察对象的血清PⅠCP的浓度。结果　黑龙江省慢型克山病患者血清PⅠCP浓度 (56.42± 8.10 ) μg/L显著高于病区正常人 (49.2 1± 4.98) μg/L(P <0 .0 1) ;病区正常人的血清PⅠCP浓度显著高于非病区正常人(40 .85± 6.75) μg/L(P <0 .0 0 1)。四川省病区正常儿童血清PⅠCP(52 .53± 12 .91) μg/L高于非病区正常儿童(45.91± 6.0 2 ) μg/L ,但无统计学意义 (P >0 .0 5)。结论　慢型克山病患者机体胶原合成活跃 ,血清PⅠCP有可能成为监测慢型克山病的一个指标 ;病区正常人机体胶原代谢异常及其意义值得进一步研究更多还原

【Abstract】 ObjectiveTo investigate the change of serum concentration of procollagen type Ⅰ carboxy-terminal peptide (PⅠCP) of patien ts with chronic Keshan disease.MethodsPⅠCP levels of patients with chronic Kehsan di sease and healthy persons in endemic area and non-endemic area of Keshan diseas e in Heilongjiang province were measured by ABC-ELISA, and PⅠCP levels of chil dren in endemic area and non-endemic area of Keshan disease in Sichuan province were also measured.ResultsPⅠCP levels of patients with chronic Keshan di sease were significantly higher than those of healthy persons in endemic area, i n turn, than those of healthy persons in non-endemic area in Heilongjiang provi nce(P<0.01). PⅠCP levels of children in endemic area were higher than those of children in non-endemic area in Sichuan province, but no statistical significance was found(P>0.05).ConclusionsThe measurement of serum concentrations of PⅠCP may reflect the collagen synthesis in patients with chronic Keshan disease and may be a new marker in monitoring chronic Keshan disease; abnormal metaboli sm of collagen in the healthy persons in endemic area need to be studied in deta il.更多还原