【摘要】 目的　查明全民食盐加碘后贵州省儿童甲状腺肿大 (甲肿 )率消长反常现象的原因。方法　采用点面结合的“典型调查”方法 ,即先用触诊法初筛贵州省 19所小学校的适龄儿童 ,然后从中遴选出 度甲肿率较高的并有层次代表性的 3所学校纳入全面调研的视野。结果　儿童甲肿率消长反常现象在贵州省较为普遍 ,甲肿病情严重程度的排序是村屯级 >乡镇级 >县城级 >省城级。结论　高甲肿率与当地多种因素密切相关 ,水硬度大、辣椒氟严重超标以及贫困等因素在致病过程中发挥着修饰性放大作用。这一结论有待进一步通过病例对照研究和前瞻性队列研究证实。更多还原

【Abstract】 Objective To find out the cause for sustainable high goiter rate of children after longer time implementation of universal salt iodization program in Guizhou province.Methods According to the children’s goiter rate by palpation screening in 19 schools, it was focused on 3 representative schools and their locations at different levels as village, township and county.Results It was discovered that the phenomenon of children’s sustainable high goiter rate was widely existed in Guizhou province, and the order of goiter rate from low to high was city, county, town and village.Conclusions The high goiter rate was closely related to several local factors and the high calcium level in drinking water, high fluorine level in chili and poverty are influence factors, playing an amplifying role in the pathogenesis. This conclusion needs to be confirmed by further case-control study and cohort study.更多还原