【摘要】 用溶剂挥发法制备了包裹利福平的聚乳酸微球。研究了聚乳酸的分子量、药物含量、微球粒径、释放介质pH值对微球释药性能的影响。结果表明 ,聚乳酸分子量大较难降解 ,其释药速率较慢 ;利福平含量增大 ,微球内外药物浓度梯度大 ,药物的释放较快 ;微球粒径越小 ,释药越快 ;介质呈碱性时聚乳酸的降解较快 ,利福平的溶解度较大 ,释放亦快更多还原

【Abstract】 Polylactic acid(PLA) microspheres(MS) were prepared by an oil-in-water solvent evaporation method to encapsulate rifampin(RFP). Effects of molecular weight of PLA, the drug content, microsphere size, pH value of medium on the drug-releasing performance of the PLA microspheres were investigated. The results showed that the greater the molecular weight of PLA, the less it degrades and the more slowly the drug release. Again, the greater the content of RFP and the greater the difference of drug concentration between in and out of the microsphere, the more quickly the drug releases. The smaller the microsphere size, the more quickly the drug releases. In the alkali medium, the PLA degrades more quickly, and RFP becomes more stable, resulting in the faster release of drug.更多还原