【摘要】 采用紫外 可见光谱滴定法测定了 β 环糊精 ( β CD)在 1 0℃ ,不同 pH值条件下包合苯丁酸氮芥(CHL)的稳定常数 ,探索了主客体分子间的作用机理。研究表明 ,在不同pH值条件下 β CD与CHL均形成1∶1的包合物 ,且在 pH =4时 ,β CD对CHL有较强的包合能力。另外 ,在 2种不同温度和介质中 ,制备了其固体包合物 ,经DSC、XRD分析证实了包合物的形成 ,TLC检测进一步确证了包合物的组成 ,同时证实了在低温条件下 ,醇水混合介质能够有效地避免苯丁酸氮芥的水解更多还原

【Abstract】 UV-vis spectrophotometric titration was used to calculate the stability constants of an inclusion complex of β-cyclodextrins(β-CD) with chlorambucil(CHL) in different pH buffer solutions at 10 ℃. The stoichiometry of the inclusion complexes appeared to be 1∶1. It was found that there is a stronger inclusion effection in pH=4 buffer solution. Two solid inclusion complexes were obtained with different preparation conditions . The results of DSC and powder X-ray diffraction measurements indicated that novel crystalline structures of inclusion complex were formed under two different conditions . TLC was used to analyze the components of the solid complexes. The results indicated that the hydrolysis of CHL can be efficiently avoided under the low temperature using mixture solvent of alcoholate and water.更多还原