【摘要】 目的:制备治疗滴虫感染的奥硝唑生物粘附性缓释栓,并制定其质量控制标准。方法:以PEG-600,PEG-6000,CMC-Na为栓剂基质,奥硝唑为主药制成栓剂,并用紫外分光光度法测定主药的含量。结果:低、中、高3种浓度的平均回收率分别为99.92％,98.76％,100.61％,RSD分别为0.08％,1.24％,0.61％。结论:奥硝唑生物粘附性缓释栓制备工艺简单,栓剂成型性好,含量测定方法可行,结果可靠。更多还原

【Abstract】 Objective: To prepare ornidazole biological adhesive sustained release suppository for treatment trichomonas infection, and enact its standard of quality control, Methods: PEG - 600, PEG - 6000, CMC - Na as suppository base, ornidazole as principal drug, to prepare suppository, and assay the content of ornidazole by UV spectrophotometry. Results: The recover rates of low, medium, high concentration are 99.92% ,98.76% ,100.61% respectively, RSD are 0. 08% , 1. 24% ,0. 61% respectively. Conclusion: The preparation craft of ornidazole biological adhesive sustained lease suppository is simple, shaping ability of suppository is good, content assay method is applicable and reliable.更多还原