【摘要】 目的:探讨注射用头孢呋辛钠的稳定性。方法:通过加速、温度、光照、充氮影响实验,以含量(％)、聚合物(％)、溶液的颜色和澄清度为指标,考察不同原料厂家注射用头孢呋辛钠的稳定性。结果:样品A的含量变化最小,其溶液的澄清度和颜色最好,3个样品的聚合物(％)则相差不大。结论:头孢呋辛钠原料质量是影响产品稳定性的主要因素。更多还原

【Abstract】 Objective: To study the stabilities of cefuroxime sodium for injection. Methods: Using drug and polymer content,color and clarity of solution as the quality indexes,the stabilities of cefuroxime sodium for injection made by different raw materials from different suppliers were investigated by accelerated experiments and influencing - factor tests, including temperature, light and nitrogen. Results: The results showed that the drug content of sample A hardly changed and its clarity and color of solution were the best, the polymer contents had no apparent difference among three samples. Conclusion: The quality of cefuroxime sodium raw material has great influence on the stabilities of products.更多还原