【摘要】 目的 :研究 4种莲心碱衍生物抗心律失常的药理作用。方法 :采用哇巴因、氯化钙、乌头碱 3种抗心律失常模型。结果 :4种莲心碱衍生物 (5mg·kg 1 ,iv)均能显著提高哇巴因致豚鼠、乌头碱致大鼠发生室性期前收缩 (VE)、室性心动过速 (VT)、心室纤颤 (VF)及心脏停搏 (CA)的用量 ,延长CaCl2 诱发大鼠心律失常的出现时间 ,缩短生存大鼠的窦性心律恢复时间 ,减少死亡率。结论 :4种莲心碱衍生物均有广泛的抗心律失常作用。更多还原

【Abstract】 Objective:To study the antiarrhythmic effects of four liensinine’s derivatives. Method:Experiments were performed in three arrhythmic animal models: ouabain-induced arrhythmia in guinea pigs, CaCl₂-induced and aconitine-induced arrhythmia in rats. Results:The four liensinine’s derivatives （5 mg·kg -1 , iv） could markedly increase the threshold dose of ventricular extrasystole （VE）, ventricular tachycardia （VT）, ventricular fibrillation （VF） and cardiac arrest （CA） caused by ouabain in guinea pigs and aconitine in rats; delay the oneset time of arrhythmia and shorten the recovering time of normal heart rate and mortality of CA caused by CaCl₂ in rats. Conclusion:The four liensinine’s derivatives have extensive antiarrhythmic effects.更多还原