【摘要】 目的 :观察黄芪注射液联用甲钴胺治疗糖尿病周围神经病变 (DPN)的疗效。方法 :治疗组 68例 ,给予黄芪注射液 40mL ,加入 0 .9%氯化钠注射液 2 5 0mL ,静脉滴注 ,qd ,联用甲钴胺注射液 5 0 0 μg ,im ,qd ,疗程 3 0d ;对照组 2 4例 ,单用甲钴胺 ,用法、疗程同治疗组。观察两组对DPN患者腱、膝反射 ,自觉症状改变及对肌电图、空腹血糖 (FBG)的影响。结果 :治疗组显效率 5 4.4% ,对照组 2 0 .8% (P <0 .0 1) ;治疗组总有效率 88.2 % ,对照组 62 .5 % (P <0 .0 5 ) ;治疗后 ,治疗组的肌电图运动传导速度 (MNCV)及感觉传导速度 (SNCV)明显增加 (P <0 .0 1) ,对照组增加 (P <0 .0 5 ) ;治疗组FBG略有下降 (P >0 .0 5 )。结论 :黄芪注射液联用甲钴胺治疗DPN比单用甲钴胺疗效更好。更多还原

【Abstract】 Objective:To study the effect of huangqi injection combined with mecobalamin on diabetic peripheral neuropathy(DPN). Methods:The treatment group, 68 cases, were given huangqi injection 40 mL added with 0.9% sodium chloride injection 250 mL q.d. by intravenous drip in combination with mecobalamin injection 500 μg, q.d. for 30 d. The control group, 24 cases, were given mecobalamin alone in the same dosage as for the treatment group. Observe the tendon-jerk reflexes, subjective symptoms, electromyography, and FBG in the two groups. Results:Marked effective rates were 54.4% in the treatment group and 20.8% in the control group( P <0.01). Effective rates were 88.2%(treatment group) and 62.5% (control group)( P <0.05). Electromyography movement-neural conductive velocity (MNCV) and sensation-neural conductive velocity (SNCV) were markedly increased in the treatment group after treatment ( P <0.01) and were increased in the control group ( P <0.05). FBG fell slightly without meaning in statistics in the treatment group after treatment ( P >0.05). Conclusion:The effect of huangqi injection combined with mecobalamin on DPN is better than that of mecobalamin alone.更多还原