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二味康口服液对放疗后荷瘤小鼠免疫增强作用

Immunoenhancement Effect of Erweikang Oral Solution on Tumor-bearing Mice after Radiotherapy

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【作者】 徐丽君袁红琳魏世超马宝瑕沈关心

【Author】 XU Li-jun 1, YUAN Hong-lin 2, WEI Shi-chao 3, MA Bao-xia 3, SHEN Guan-xin 2(1. Institute of Combination of Chinese Traditional and Western Medicine ; 2. Department of Immune, Basic Medical College ; 3. Department of Pharmacy, Tongji Hospital, Affiliated with the Tongji Medical College, Huazhong University of Science &Technology, Wuhan 430030, China )

【机构】 华中科技大学同济医学院附属同济医院中西医结合研究所华中科技大学同济医学院基础医学院免疫教研室华中科技大学同济医学院附属同济医院药学部华中科技大学同济医学院基础医学院免疫教研室 武汉430030武汉430030武汉430030

【摘要】 目的 :研究二味康口服液 (下简称二味康 )对放疗后荷瘤小鼠免疫功能的增强作用。方法 :采用昆明种小鼠制备艾氏腹水癌模型 ,荷瘤小鼠应用6 0 Co 8Gy剂量 ,分 2次全身照射 ,并协同二味康灌胃治疗 ,观察小鼠免疫功能变化。结果 :放疗后反映小鼠淋巴细胞转化程度的刀豆蛋白A(ConA)、脂多糖 (LPS)刺激指数 (SI)和NK细胞活性均有所下降 ,但放疗加二味康组SI值及NK细胞活性明显高于放疗组 (P <0 .0 5 ,P <0 .0 1)。结论 :二味康对放疗后荷瘤小鼠免疫功能有增强作用。

【Abstract】 Objective:To study the immunoenhancement of erweikang oral solution (EOS) on tumor-bearing mice after radiotherapy. Method:The EAC-cancer model was made with kunming mice. The tumor-bearing mice were treated with radiation (8 Gy) and EOS, and the changes in immunologic function were observed. Results:The stimulation index (SI) of Con A and LPS and the activity of NK cell declined after radiotherapy, but they were much higher in radiotherapy+medicine groups than in radiotherapy groups( P <0.05, P <0.01). Conclusion:EOS can enhance the immunologic function of tumor-bearing mice from destruction by radiation.

  • 【文献出处】 医药导报 ,Herald of Medicine , 编辑部邮箱 ,2003年09期
  • 【分类号】R73-36
  • 【被引频次】1
  • 【下载频次】26
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