【摘要】 目的 :评价阿奇霉素治疗小儿支原体肺炎的临床疗效和安全性。方法 :支原体肺炎患儿 80例 ,随机分为治疗组和对照组各 40例 ,进行单盲对照试验 ,治疗组给予注射用阿奇霉素 10mg·kg 1 ·d 1 ,用 0 .9%氯化钠注射液稀释为 1～ 2mg·mL 1 ,分 2次 ,q 12h ,静脉滴注 ,每次滴注时间不少于 60min ,3～ 7d后改为阿奇霉素口服 ;对照组用红霉素 15～ 3 0mg·kg 1 ·d 1 ,用 10 %葡萄糖注射液或 0 .9%氯化钠注射液稀释为 1mg·mL 1 ,静脉滴注。两组均以治疗 7～ 10d为 1个疗程。结果 :治疗组和对照组的 3d显效率分别为 72 .5 % ,3 7.5 % ;7d治愈率分别为 5 0 .0 % ,2 3 .7% ;10d治愈率分别为95 .0 % ,77.5 % ;不良反应发生率分别为 10 .0 % ,3 0 .0 % ,并且对照组 2例因严重不良反应而停药。结论 :与红霉素相比 ,阿奇霉素治疗小儿支原体肺炎具有疗效高、不良反应发生率低、起效快等优点。更多还原

【Abstract】 Objective:To evaluate the clinical therapeutic effectiveness and safety rate of azithromycin in the treatment of mycoplasmal pneumonia in children. Methods:80 patients with mycoplasmal pneumonia were randomly divided into 2 equal groups with 40 children each. The study was carried out with the mono blind method. Patients of the treatment group were given each a daily dose of 10 mg·kg 1 of azithromycin which was diluted to a concentration of 1～2 mg·mL 1 with 0.9% sodium chloride solution and administered by IV instillation q 12 h. Each instillation lasted no less than 60 min. 3～7 days later azithromycin was given PO. Patients of the control group were given each a daily dose of 15～30 mg·kg 1 of erythromycin diluted with 10% glucose solution or 0.9% sodium chloride solution to a concentration of 1 mg·mL 1 and administered by IV instillation. The course of treatment in both groups lasted 7～10 days. Results:The rates of excellent therapeutic effectiveness on day 3 were 72.5% and 37.5% in patients of the treatment group and control group, respectively. The cure rates on day 7 were 50.0% and 23.7%, while those on day 10 were 95.0% and 77.5% in patients of the treatment group and control group, respectively. The incidences of adverse reactions were 10% and 30% in patients of the treatment group and control group, respectively. Erythromycin was discontinued in 2 patients of the control group owing to severe adverse reactions. Conclusion:Azithromycin was shown to have the advantages of quick action, high curative effect and low incidence of adverse reactions in the treatment of childhood mycoplasmal pneumnonia as comparel with erythromycin.更多还原