【摘要】 目的　分析阴沟肠杆菌耐药机理和现状 ,指导临床合理应用抗菌药物。方法　用K B纸片扩散法对1 32株阴沟肠杆菌做 2 0种抗菌药物的敏感试验 ,并对 80株阴沟肠杆菌进行超广谱 β 内酰胺酶 (ESBLs)测定。 结果　对 2 0种抗菌药物的敏感试验显示 ,阴沟肠杆菌对 β 内酰胺类抗生素显示较高耐药 ;对氨基糖苷 ,喹诺酮类等也有不同程度的耐药 ,对碳青霉烯类有很高的抗菌活性。结论　阴沟肠杆菌对临床常用的抗菌药物呈高耐和多重耐药 ,其耐药机制为 β 内酰胺酶产生的ESBLs和AmpC酶 ;环丙沙星、左氟沙星、头孢吡肟等可作为治疗其感染的首选用药 ,亚胺培南可作为二线用药 ,治疗其混合感染及其高耐菌株更多还原

【Abstract】 Objective To analyze drug resistant mechanism and situation and direct clinical prudent using of antibiotics. Methods By using paper disc diffusion method, 132 clinical strains of E.cloacae were tested for susceptibility,and 80 strains of E.cloacae were detected for the production of ESBLs.Results The susceptibility test results showed, All E.cloacae isolated had a relatively high resistance to β lactamase, and carbopenem had high antibioltic activity.Conclusions Clinical strains showed multiresistance to usual antibiotics, and Quinolone and Cefepime may be used as the leading antibiotics, and Imipenem is the second choice.更多还原