【摘要】 目的　观察粉防己碱 (Tet)和依那普利 (Ena)对高血压大鼠血管重构的逆转作用。方法　用两肾一夹(2K1C)法制备肾血管性高血压 (RH)大鼠病理模型 ,组织切片图像分析法评价大动脉、小动脉和阻力血管结构改变及药物的影响。结果　RH大鼠主动脉、尾动脉和股动脉湿重增加 ;腹主动脉、尾动脉、心脏冠脉小血管、肾小动脉和肠系膜 3级小动脉横截面积、中膜厚度和壁 腔比值均明显增大 ,肾小动脉管壁平滑肌细胞 (VSMC)数明显增加。 2K1C术后 9周给予Tet或Ena连续 9周 ,上述血管变化明显减轻。结论　RH大鼠各级动脉均呈肥厚性重构 ,肾小动脉管壁伴有VSMC增生 ;Tet和Ena可有效逆转RH大鼠血管重构更多还原

【Abstract】 Aim To observe the regression effect of tetrandrine (Tet) and enalapril (Ena) on vascular morphological changes in renovascular hypertensive (RH) rats. Methods Renovascular hypertension was induced by two kidney one clip (2K1C) operation. The morphometric measurements were performed in the aorta, caudal artery, renal arterioles, coronary arterioles and mesenteric arterioles. Results The wet weight of aorta, caudal artery and femoral artery of RH rats (18 weeks after 2K1C operation) were greater than those of sham operated rats. The media thickness, lumen diameter, cross section of media, media over lumen ratio and the wet weight of abdomen aorta, caudal artery, coronary arterioles, renal arterioles and mesenteric arterioles were significantly increased, which were more significant in arterioles with the diameter smaller than 70 μm. There were no significant change in the number of the smooth muscle cells (VSMC) in most vessel wall, except in renal arterioles, where the number of smooth muscle cells were significantly increased. After Tet (50 mg·kg -1 ·d -1 , po ) or Ena (6 mg·kg -1 ·d -1 , po ) treated for 9 weeks from week 9 after 2K1C operation, almost all the changes in the media thickness, the media to lumen ratio, the cross section of media and the wet weight were ameliorated. Conclusion In RH rats, mainly a hypertrophic and rearrangement remodeling in the wall of arteries and arterioles was observed with a proliferation of VSMC in renal arterioles. Tet and Ena were shown to regress vascular remodeling by markedly attenuating these changes in renovascular hypertensive rats.更多还原