【摘要】 目的　研究含N 乙基 2 甲基 5 硝基咪唑的诺氟沙星、环丙沙星和依诺沙星衍生物的合成及其抗菌活性。方法　用含 2 甲基 5 硝基咪唑的诺氟沙星、环丙沙星和依诺沙星等为原料 ,通过亲核取代、酯化合成目的物 ;测定目的物的抗菌活性。结果　设计、合成了 9个新化合物 (IIa～c ,IIIa～f) ,其结构经MS ,1 HNMR和元素分析确证。化合物IIa～c的体内抗菌活性较明显。结论　化合物IIa～c显示了一定的体内抗菌活性 ,值得进一步研究更多还原

【Abstract】 Aim To study the synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2 methyl 5 nitroimidazol. Methods Pyridonecarboxylic acid derivatives containing 2 methyl 5 nitroimidazol were synthesized primarily from 2 methyl 5 nitroimidazol, norfloxacin, ciprofloxacin, enoxacin via nucleophilic substitution and esterification. The antibacterial activity of the nine target compounds were tested. Results Nine new compounds were synthesized (IIa～c and IIIa～f). The structure of the title compounds were identified by 1HNMR , MS as well as elementary analysis. Conclusion Compounds IIa, IIb and IIc showed antibacterial activity, and were worth further studying.更多还原