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金钱草中黄酮苷的分离与结构鉴定

Isolation and structure identification of flavonol glycoside from Lysimachia christinae Hance.

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【作者】 崔东滨王淑琴严铭铭

【Author】 CUI Dong bin, WANG Shu qin, YAN Ming ming (Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province, Changchun 130021, China)

【机构】 吉林省中医中药研究院吉林省中医中药研究院 吉林长春130021吉林长春130021吉林长春130021

【摘要】 目的 从金钱草中分离制备标准品。方法 用硅胶柱色谱进行分离 ,通过理化方法及IR ,UV ,MS ,1 HNMR ,1 3CNMR ,DEPT ,HMQC ,HMBC等光谱分析确定化合物结构。结果 从金钱草中分离得到 2个化合物 ,分别鉴定为鼠李酮酸γ 内酯 (I)、山奈酚 3 O α L 鼠李糖 (1→ 2 ) β D 木糖苷 (II)。 结论 II为新化合物 ,命名为金钱草素 ,I为首次从该属植物中分离得到

【Abstract】 Aim To isolate and prepare chemical standards. Methods Flavonol glycoside and rhamnonic acid γ lactone were isolated from whole plants of Lysimachia christinae Hance. with 95% ethanol and purified by silica gel column chromatography. UV, IR, MS, 1HNMR, 13 CNMR, DEPT, HMQC, HMBC were used for the structural identification. Results Two compounds were obtained. They were identified as rhamnonic acid γ lactone (I) and kaempferol 3 O α L rhamnosyl (1→2) β D xyloside (II). Conclusion Compound I was isolated from this genus for the first time. Compound II is a new compound named as lysimachiin.

【基金】 国家科技部重点项目中药现代化研究与产业化开发(99-92 9-0 1-3 0 )
  • 【文献出处】 药学学报 ,Acta Pharmaceutica Sinica , 编辑部邮箱 ,2003年03期
  • 【分类号】R284
  • 【被引频次】42
  • 【下载频次】615
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