【摘要】 [目的 ]探讨L 肉碱对肥胖大鼠体重、体脂含量及血脂水平的影响。 [方法 ]以高脂饲料诱导大鼠肥胖模型 ,然后将肥胖大鼠随机分为对照组与 12 5、2 5 0、5 0 0mg/kg体重 3个L 肉碱组 ,每天 1次经口给予 ,共 6周。观察大鼠体重、睾丸 +肾脂肪垫合计重量 ,TC、TG和HDL C水平的变化。 [结果 ] 12 5、2 5 0、5 0 0mg/kg剂量组动物的体重与甘油三酯 (TG)低于对照组 ;2 5 0、5 0 0mg/kg剂量组的睾丸 +肾脂肪垫重量低于对照组 ;5 0 0mg/kg剂量组的胆固醇 (TC)、高密度脂蛋白胆固醇 (HDL C)和体脂比低于对照组。 [结论 ]L 肉碱具有改善大鼠肥胖与降低高血脂水平的作用。更多还原

【Abstract】 [Objective]To investigate the effects of oral L-carnitine (LC) supplement on body weight,fat content and blood lipid in obese rats. Male Wistar obese rats, Induced by abundant fat food, were randomly divided into four groups and supplemental oral LC was given in the 0,125,250,500 mg/kg body weight groups respectively for six weeks. Body weights of obese rats, fat pads around kidney and testis and blood lipids were measured. Body weight and TG of all LC supplementation groups decreased obviously compared with the control. Fat-pads in the 250 mg/kg and 500 mg/kg groups were lower than that in the control group. The HDL-C of 500 mg/kg group was lower than that in the control group. On the other hand, TC of 500 mg/kg group was lower compared with the control.[Conclusions] LC can decrease weight and reduce blood lipids in obese rats.更多还原