【摘要】 目的 :从分子水平探讨曲马朵急性戒断机理及 5 -羟色胺酸、育亨宾对曲马朵急性戒断反应的影响。方法 :利用RT -PCR技术研究小鼠大脑皮层 μ受体mRNA表达的变化。 结果 :曲马朵急性戒断小鼠 μ受体mRNA的表达明显升高 ,增加了 15 3.3% ,而育亨宾和 5 -HTP可抑制曲马朵急性戒断诱导的 μ受体mRNA改变。 结论 :中枢 5 -羟色胺系统和去甲肾上腺素系统对曲马朵急性戒断诱导的小鼠大脑皮层 μ受体mRNA高表达具有调节作用更多还原

【Abstract】 Objective: To study the possible molecular mechanisms underlying acute tramadol abstinence and the effect of 5-hydroxyptrytophan and yohimbine upon acute tramadol withdrawal. Methods: The expression of μ receptor mRNA in cerebral cortex of mice was investigated by RT-PCR. Results: In acute tramadol abstinence mice, the expression of μ receptor mRNA was 153.3% higher than that of control mice, while yohimbine and 5-hydroxyptrytophan inhibited the up-regulation of μ receptor gene expression induced by acute tramadol abstinence. Conclusion: The serotonergic and adrenergic systems in the CNS could regulate the high expression of μ receptor mRNA induced by acute tramadol abstinence in cerebral cortex of mice.更多还原