【摘要】 Cathelicidins是一族在哺乳动物中发现的含有保守的cathelin区域的抗菌肽 ,是宿主防御系统的重要组成部分 ,具有广谱且强大的抗菌活性。文章综述了cathelicidins抗菌肽家族的基因组成、结构、抗菌活性、作用机制及构效关系等更多还原

【Abstract】 Cathelicidins, a family of mammalian antimicrobial peptides that carry a highly conserved cathelin domain, are important components of host defense immunity system. They exert a broad spectrum and potent antimicrobial activities. This review is aimed at providing a general overview of cathelicidins , with emphasis on aspects such as biosynthesis genes ,structural features ,antimicrobial spectrum , mechanism of action and structure/activity relationship studies.更多还原