【摘要】 目的:探讨黄酮类化合物水飞蓟宾(SB)对阿霉素(Dox)所致小鼠心肌毒性的影响,为临床上防护Dox毒性提供依据。方法:以Dox处理的昆明种小鼠为模型,测定预先给予SB的小鼠血清肌酸激酶(CK)、谷草转氨酶(AST)活性以及心脏丙二醛(MDA)含量变化。结果:SB可拮抗Dox所致CK、AST活性升高,并能降低心脏MDA含量。结论:SB能明显减少Dox诱发的心肌脂质过氧化物的形成,从而显著减轻其心脏毒性。更多还原

【Abstract】 Objective: To study the alleviative effects of silibinin(SB), one of the flavonoid chemicals, on the cardiac toxicity to mouse, which was caused by doxorubicin(Dox). Method: Compared with the Kunming mice treated with Dox, the content changes of blood serum creatine kinase(CK), aspartate aminotransferase (AST)and cardiac MDA were determined in mice by administration of both Dox and SB. Results: SB could antagnize the activity increasing of CK and AST which was caused by Dox, and significantly lower the level of MDA in heart. Conclusion: SB can reduce the formation of lipid peroxiation, thus alleviating cardiac toxicity markedly.更多还原