【摘要】 探讨克林霉素的不良反应(ADR)及其用药安全性。方法:通过将248例ADR病例按WHO ADR器官/系统类型分类后,对其ADR临床表现、并用药物与ADR发生机制以及克林霉素的安全性进行分析探讨。结果:248例ADR病例症状涉及15个器官/系统类型,前三位是皮肤及其附件损害、胃肠系统损害及中枢和外周神经系统损害。结论:应重视克林霉素的合理用药,警惕临床应用中可能因本品的药物相互作用诱发严重ADR的潜在危害性。更多还原

【Abstract】 To evaluate the side-effects induced by clindamycin and its safety in clinical practice. Method:According to organ/system types recommended by WHO, the adverse reactions of clindamycin in 248 cases were classified. Results; 15 organs/systems were involved and the commonest ADRs were damages of skin and its appendages, digestive system, central and peripheral nervous system. Conclusion; Clindamycin should be used with caution in patients with a history of hypersensitivity. There is a potential danger of significant diarrhoea, hematuria and respiratory depression mainly because of drug interactions.更多还原