【摘要】 目的　研究急性胰腺炎时血浆内皮素 (ET)、一氧化氮 (NO)变化和丹参对其影响 ,并探讨丹参对急性胰腺炎(AP)治疗作用。方法　急性胰腺炎 71例 ,随机分为治疗组 36例 (A组 ) ,观察组 35例 (B组 )。A组用基础治疗 +丹参 +6 5 4- 2 ;B组除丹参外治疗方法与A组相同。两组治疗前后均应用放射免疫分析方法测定血浆ET、NO和血尿淀粉酶 (somogyi) ,同时以健康体检者 15例 (C组 )作对照。结果　急性胰腺炎时血浆ET、NO较C组明显增高 ,其增高程度与AP病变程度相关。A组经丹参治疗后血浆ET、NO变化较B组具有显著性差异 (P <0 .0 1) ;血尿淀粉酶恢复正常值时间、病程的缩短和治疗费与B组相比亦具统计学意义。结论　血浆ET、NO异常变化可能是AP发生、发展主要因素之一。丹参具有改善胰腺微循环和拮抗ET、NO产生 ,对AP有一定治疗作用。更多还原

【Abstract】 Objective To study changes of endothelin (ET),nitric oxide (NO) in plasma and tanshinon for treatment of acute pancreatitis(AP).Methods Seventy-one patients with AP.A(n=36) randomimental group,the patients were given Tanshinon+anisondamine hydrobromide+treated base and group B(n=35) with anisondamine hydrobromide+treated base.ET and NO were measured by the methods of analysis of radioimmunoassay preformed in all patients and after the treatment.Group C(n=15) normal controls(NC).Results The levels of ET and NO increased significantly in AP,NC significen difference.The levels of ET and NO decreased for Treatment and group B significen difference (P< 0.01).Comparing with group B,group A had the obviously shortened mea increased of plasma and uric amylase and course time,therapy to spend (P<0.01).Conclusion The plasma ET,NO and SOD might all play a key role in the development of AP.Therapeutical effect posse of tanshinon in AP.=更多还原