【摘要】 肿瘤坏死因子受体相关因子(TRAFs)是经TNF受体超家族和IL-1R/TLR超家族信号传导通路的重要成分.TNF信号传导中,TRAF2作为接头蛋白和调控因子在几乎所有分支通路中起作用,在调节TNF-R1介导的NF-κB和JNK激活过程中起重要作用.近来的研究提示,TRAF2是凋亡信号传导和抗凋亡信号传导的分支点.本文主要阐述TRAF2的分子结构及它的结构与功能的关系,TNF信号传导的分子机制及TRAF2在其中的作用,重点关注TRAF2作为凋亡途径和NF-κB介导的存活途径,即这2条相互拮抗的信号传导途径的分支点的重要性.更多还原

【Abstract】 The tumor necrosis factor receptor associated factors(TRAFs) have emerged as the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like recepor (IL-1R/TLR) superfamily.In TNF signaling pathway,TRAF2 as adapter proteins and regulation factors are important to nearly all pathways,having a key role in mediating TNF-R1-induced activation of NF-κB and JNK.Recent studies suggest that TRAF2 represents an integration point for proand antiapoptatic signals.This review focuses on the molecular structure of TRAF2,the relationship between its structure and function,the molecular mechanisms and the role of TRAF2 in TNF signaling, and highlights the importance of this molecule for the integration of such antagonizing pathways as death induction and NF-κB-mediated surviving signals.更多还原