【摘要】 目的 :观察洛沙坦 (losartan)对抗小鼠艾氏腹水癌 (EAC)的作用。方法 :采用昆明种小鼠 ,随机分组进行实验 ,分别观察洛沙坦对体内艾氏腹水癌实体瘤的抑瘤率和艾氏腹水癌生存期延长率的作用 ,并与 5 FU和生理盐水对照。结果 :洛沙坦 (1 2 .5mg·kg- 1 )对小鼠体内艾氏腹水癌实体瘤有显著的抑瘤作用 ,抑瘤率达 46.3 % ,阳性对照药 5 FU(5mg·kg- 1 )的抑瘤率为 3 1 .5 % ;但洛沙坦对艾氏腹水癌生存期延长率无明显影响 ,阳性对照药 5 FU(5mg·kg- 1 )生存期延长率为 42 .9%。结论 :洛沙坦对动物移植性肿瘤艾氏腹水癌 (EAC)的实体瘤有显著的抑瘤作用 ,但对腹水癌无提高生存期延长率的作用 ,推测其抗肿瘤作用可能是通过抑制肿瘤血管生长而发挥作用。更多还原

【Abstract】 AIM: To study the antitumor e ff ects of losartan in EAC mice. METHODS: The inhibitory rates of t umor growth and the ratio of extending viability were observed in EAC mice in th ree groups given losartan, 5-FU and NS, respectively. RESULTS: Comparing with the control groups, the inhibition to tumor growth was 46.3 % in losartan ( 12.5 mg·kg -1 ) group. But losartan did not lengthen life time in EAC mice. The inhibition to tumor growth was was 31.5 % in 5-F U (5 mg·kg -1 ) group. CONCLUSION: Losartan can inhibit the tumor growth of EAC, but not lengthen life time of the animals.更多还原