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孕烷X受体和CYP3A相关性的研究进展
Progresses of researches on the correlation between pregnane X receptor and CYP3A
【摘要】 CYP3A是生物体内化学物代谢的关键酶 ,孕烷X受体 (PXR)是CYP3A基因表达的转录活化因子。PXR分子结构的不同导致CYP3A的种属差异。化学物通过PXR调节CYP3A的表达可能是影响化学物体内代谢的一条重要途径。研究PXR和CYP3A的相互作用对于新药设计、指导临床合理用药、预测药物相互作用、减少药物不良反应都具有重要意义。
【Abstract】 Cytochrome P450 monooxygenase 3A(CYP3A) is one of the key enzymes for the metabolism of endogenous steroids and foreign chemicals in liver. Pregnane X receptor(PXR) is a critical regulator of CYP3A gene expression and activation of PXR is predictive of CYP3A induction. Sequence differences in the ligand binding domain of PXR serve as the molecular basis for the species difference in CYP3A induction. Studies on the correlation between CYP3A and PXR would have practical applications especially in the direction of clinical drug usage.
- 【文献出处】 中国药理学与毒理学杂志 ,Chinese Journal of Pharmacology and Toxicology , 编辑部邮箱 ,2003年03期
- 【分类号】R96
- 【被引频次】11
- 【下载频次】377