【摘要】 合成了一系列的 1 芳基 1,4 二氢 3 芳酰肼基甲酰基 6 甲基 4 哒嗪酮类化合物 ,并用离体黄瓜子叶生根法测试其生物活性 ,生测结果表明 ,所有的化合物均显示出一定的生物活性 ,并且芳环上的取代基对活性有重要影响 .采用化合物的物理化学参数及化合物促进黄瓜子叶生根的活性 ,进行了结构与活性定量关系研究 ,建立了较好的结构与活性的相关式 ,化合物的亲脂性和取代基的电性对化合物的生物活性具有重要的影响 .研究结果对 3 芳酰肼基甲酰基 4 哒嗪酮类化合物的改性或新类似物的合成具有指导意义 .更多还原

【Abstract】 A series of 1-aryl-1,4-dihydro-3-acylhydrazinocarbonyl-6-methyl-4-pyridazinones, related to the plant growth regulating effect (GRE), were synthesized and tested in excised Cucumber cotyledon root-formation. The bioassay shows that the title compounds possess promoting Cucumber cotyledon root-formation activity. And the activity was influenced by the nature of the substituents. The quantitative relationship between the structure of the compounds and their GRE activity was analyzed, using the physicochemical parameters of the substituents and regression analyzed. The result shows that both hydrophobic parameter and electronic parameter of the substituents are the major one in affecting the activity. This offers important structural insights into designing highly active compounds prior to their synthesis.更多还原