【摘要】 目的 应用累积Meta分析的方法探讨非小细胞肺癌完全切除术后含铂辅助化疗方案的价值。材料和方法 在MEDLINE、Cochrane图书馆、ASCO、ESMO的官方网站或Education book及CBMdisc数据库检索有关非小细胞肺癌完全切除术后随机分为含铂化疗对随访或者是含铂化放疗对放疗的前瞻性随机对照研究。对入选的研究,按照出版或发表的时间顺序,对死亡风险率进行累积Meta分析。结果 共14项研究纳入分析,如以α=0.05为检验水准,非小细胞肺癌完全切除术后加用含铂辅助化疗与不加用含铂辅助化疗相比,死亡风险率的差异波动于统计学有意义与无意义之间。在1999年第一次出现差异有统计学意义,但是累积随后的研究,P值又大于0.05。当加入今年ASCO年会新发表的IALT研究时,P值再次小于0.05,差异有统计学意义。结论 非小细胞肺癌完全切除术后加用含铂的辅助化疗方案即使能提高患者的生存率,也是轻微的。目前仍不能推荐在非小细胞肺癌完全切除术后常规使用含铂的辅助化疗方案。更多还原

【Abstract】 Objective Discuss the value of platinum-based adjuvant chemotherapy in NSCLC patients with complete resection by cumulative meta-analysis. Material and Method Search all of RCT about platinum-based adjuvant chemotherapy vs. following-up or platinum-based adjuvant radiochemotherapy vs. platinum-based adjuvant chemotherapy on NSCLC patients with complete resection in MEDLINE,Cochrane Library,official net or Education book of ASCO, ESMO and CBM database. Then calculate the odds ratio (OR) by cumulative meta-analysis method in the sequence of publishing time. Result The difference of ratio for death fluctuates between statistical significance absence of statistical significance (α=0.05). It first presented statistical significance in 1999, and appeared again when cumulating IALT published in 39th ASCO annual meeting. Conclusion Platinum-based adjuvant chemotherapy combining the second generation chemic drugs results in a moderate improvement in survival in NSCLC patients with complete resection even if it does have. So platinum-based adjuvant chemotherapy cannot be recommended to those completely resected NSCLC patients.更多还原