【摘要】 为探讨宿主的遗传背景和幽门螺杆菌(Helicobacterpylori,H.pylori)相关胃癌的易感性之间的关系,本文采用PCR产物直接测序和PCR-RFLP的方法,检测142例山东临朐县胃癌高发人群个体(包括69例癌症患者和73例非癌个体)和93例北京正常对照个体SE基因多态性的分布特点。结果显示:sew/sew基因型在山东非癌个体和北京人群之间的分布差异具有统计学意义(P<0.01,OR=3.06,95%CI,1.28～7.30),sew/sew基因型在山东癌症病人和非癌个体之间分布频率无显著性差异,H.pylori感染状况与SE基因型的分布也无关联性。提示:sew/sew纯合突变在山东临朐人群中分布频率较高,可能为临朐人群的遗传标记之一。更多还原

【Abstract】 To study the relation between host genetic backgroud and the susceptibility to H.pylori associated gastric cancer,PCR-sequencing and PCR-RFLP were used to screen SECRETOR gene polymorphisms in 142 subjects including 69 cancer patients and 73 noncancer individuals from highrisk area of gastric cancer in Shandong and 93 control individuals from Beijing.Results showed that the difference in sew/sew distribution between noncancer individuals and Beijing population was significant(P<0.01,OR is 3.06,95% CI,1.28～7.30),but that between cancer patients and noncancer individuals was not with significance.SE gene polymorphism was not relevant to H.pylori infection.We concluded that Shandong population from highrisk area of gastric cancer shared a high distribution of sew/sew genotype,which could be considered as one of the genetic markers.更多还原