节点文献

新斯的明对小肠分泌血液中小分子物质清除率影响的实验研究

Experimental research on the effect of neostigmine on the clearance rate of small molecular substances in the blood secreted by small intestine

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 黄德彬廖泽云胡泽华李德清余昭芬李玉山

【Author】 HUANG De Bin, LIAO Ze Yun, HU Ze Hua, LI De Qing,YU Zhao Fen, LI Yu Shan (Dept of Pharmacology, Hubei Institute for Nationalities, Enshi 445000)

【机构】 湖北民族学院医学院药理学教研室湖北民族学院医学院生理学教研室湖北民族学院医学院生物化学教研室湖北民族学院医学院生理学教研室 恩施445000恩施445000恩施445000

【摘要】 目的 探讨肾功能衰竭时 ,经部分隔离小肠袢透析的有效药物。方法 将犬 10只随机分成对照组 (A)和实验组(B) ,每组 5只。对每只犬手术制作全隔离小肠袢 ,在双肾动脉阻流后 ,从静脉输入高渗样品液 ,造成电解质紊乱、氮质血症等肾功能衰竭模型。A组和B组分别在 0 5h和 5h时肌肉注射 0 9%NaCl 0 5ml和新斯的明 0 0 2 5mg·kg-1。同时对两组犬每隔 30min收集小肠液和采血 3ml,测定两组小肠液和血液中K+ 、Na+ 、Cl-、UN、CR、UA的浓度 ,计算各自清除率。结果 B组用新斯的明后分别于注射后 1 5h和6 5h时出现 2次分泌高峰 ,清除率明显高于A组 (P <0 0 1) ,而A组无明显分泌高峰 ,清除率变化不明显。结论 新斯的明能提高隔离小肠袢分泌量和增大对血液中小分子物质的清除率。在肾功能衰竭后 ,制作部分隔离小肠袢透析 (“肠袢肾”) ,新斯的明可作为透析治疗的有效药物

【Abstract】 AIM Research on effective dialysis medicine through partial isolation loop of small intestine to treat renal failure. METHODS Divide 10 dogs equally into group A and group B for comparative study: make full isolation loop of small intestine; input hypersonic sample solution through vein after blocking the renal arteries to make the man made real failure models such as electrolytic disorder, azotemia and so on. Then at 0 5 hour and 5 hours after that, inject 0 9% NaCl 0 5 ml for group A and 0 025 mg·kg -1 of neostigmine for group B. Finally collect the secretion fluid of the small intestine loop and blood samples every 30 minutes from group A and group B respectively so as to determine the density of K + ,Na +, Cl -,UN, CR,UA in the small intestine fluid and blood samples of the two groups and calculate the clearance rate of each group. RESULTS Respectively at 1 5 hours and 6 5 hours after being injected with neostigmine, group B got two secretion peaks and its clearance rate is remarkably higher than that of group A( P <0 01), which didn’t appear any secretion peak and obvious clearance rate changes. CONCLUSION Neostigmine can remarkably increase the secretion amount of isolation loop of small intestine and raise its clearance rate of small molecular substances in blood. Neostigmine can be used as effective dialysis medicine when partial isolation loop of small intestine was applied (intestine loop kidney) to treat renal failure.

【基金】 湖北民族学院重点资助项目 No [2 0 0 2 ] 0 8号
  • 【文献出处】 中国药理学通报 ,Chinese Pharmacological Bulletin , 编辑部邮箱 ,2003年10期
  • 【分类号】R96
  • 【被引频次】6
  • 【下载频次】58
节点文献中: 

本文链接的文献网络图示:

本文的引文网络