Neuropilin is a receptor both for semaphorins, which are mediators of neuronal guidance, and for VEGF, an angiogenesis factor. While the function of neuropilin in the nervous system has been characterized, its role in angiogenesis is also beginning to be elucidated. It has been shown that neuropilin and its soluble isoforms regulate tumor angiogenesis and subsequent tumor growth. This article reviews some of the structural and functional features of neuropilin and presents experimental evidences showing th...
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