【摘要】 目的　研究 2 ,3 二甲基 2 丁胺化合物对动脉平滑肌钾通道的作用 ,分析其化学结构与钾通道调节作用之间的构效关系 ,从而初步推断其是否具有钾通道开放活性。方法　在急性分离的大鼠尾动脉平滑肌细胞上 ,采用膜片钳全细胞记录技术研究脂肪胺新结构衍生物对钾通道的影响。结果　通过对 14种化合物的研究发现 ,当一侧取代基碳原子数为 3～ 5个时 ,该类化合物对钾电流有明显的增强作用。结论　具有特定化学结构的 2 ,3 二甲基 2 丁胺衍生物对钾通道有激活作用 ,为一类新结构类型的钾通道开放剂。更多还原

【Abstract】 AIM To investigate the effects of newly synthesized 2,3-dimethyl-2-butylamine derivatives on potassium channels in single arterial smooth muscle cells from rats, to analyze the relationship between the compound structures and its regulation of potassium channels and then to evaluate their activities. METHOD Under whole-cell patch clamp conditions, the influences of those compounds on potassium currents were observed on the acutely isolated tail arterial smooth muscle cells. RESULTS Those compounds with three to five carbon branched alkyl could distinctly increase the outward potassium currents. CONCLUSION 2,3-dimethyl-2-butylamine derivatives area kind of newly potassium channel openers with especially chemical structures.更多还原