【摘要】 目的 :观察生脉注射液对肺心病病人心肌损害的治疗作用。方法 :肺心病急性发作期心肌损害者 6 0例 ,分为生脉组及对照组各 30例。对照组用敏感抗生素、祛痰、平喘、改善通气功能、氧疗 ,维持电解质酸碱平衡等常规治疗。生脉组在常规治疗基础上加用生脉注射液 4 0mL + 5 %葡萄糖注射液2 5 0mL ,ivgtt,qd。结果 :生脉组和对照组治疗后羟丁酸脱氢酶 ,乳酸脱氢酶同工酶 ,肌酸磷酸激酶同工酶分别为 (16 6±s2 7) ,(5 1± 14 ) ,(19± 7)U·L- 1和(2 18± 31) ,(79± 2 1) ,(2 8± 8)U·L- 1,均较治疗前明显下降 ,且生脉组下降更显著 (P <0 .0 1)。 2组临床总有效率分别为 90 %和 77% ,差异无显著意义(P >0 .0 5 )。结论 :生脉注射液对肺心病急性发作期心肌损害具有治疗作用更多还原

【Abstract】 AIM: To observe the clinical effect of Shengmai injection for the myocardium injury of patients with chronic cor pulmonale. METHODS: Sixty patients with chronic cor pulmonale were divided into two groups: the treatment group of 30 patients and the control group of 30 patients. All patients in both groups were treated with the same routine therapy, and the treatment group combined with Shengmai injection 40 mL in 5 % glucose injection 250 mL, iv, gtt, qd. The activity of serum HBDH, LDH 1, CPK MB, the cardiac function(SV,CO,CI,EF), and the total effective rates (electrocardiogram and symptom) were observed before and after treatment. RESULTS: After treatment, the activity of serum HBDH, LDH 1, CPK MB in the Shengmai group and the control group which were (166± s 27),(51±14),(19±7) U·L -1 and (218±31),(79±21),(28±8) U·L -1 , respectively, was decreased significantly. The decreasing rate of the Shengmai group was more remarkable, compared with that of the control group ( P <0.01). Meantime, the cardiac function which apparently improved in two groups after therapy was better in the Shengmai group than that in the control group. There were no statistical differences in the total effective rates in relieving symptom and improving the ECG between two groups ( P > 0.05) . CONCLUTION: Shengmai injection has protective actions on the myocardium injury of patients with chronic cor pulmonale.更多还原