【摘要】 目的 :分析国内外文献资料中林可霉素不良反应报告的情况 ,了解林可霉素不良反应的发生规律。方法 :国内林可霉素不良反应病例 196 0年～1997年的来自于《药物不良反应 196 0～ 1997多媒体光盘》 ;1998年～ 2 0 0 1年的通过检索《中国生物医学文献数据库》获得。国外 196 0年～ 2 0 0 1年的林可霉素不良反应病例通过检索MEDLINE数据库获得。结果 :国内 196 0年～ 2 0 0 1年文献资料中共检索出 16 4例林可霉素不良反应病例 ,最多见的是休克样反应 ,亦是主要致死原因 ;国外 196 0年～2 0 0 1年共 772例林可霉素病例报告 ,最多见的是伪膜性肠炎 ,也是主要致死原因。结论 :林可霉素不良反应国内外存在一定差异 ,我国以休克样反应为最常见 ,与剂量偏大有关 ,应引起临床的重视更多还原

【Abstract】 AIM: To analyze those adverse drug reactions in the reports of lincomycin published at home and abroad and investigate the rule of adverse drug reactions of lincomycin. METHODS: The cases of adverse reaction of lincomycin in China from 1960 to 1997 were searched in “multimedia dedication adverse reaction disk”, and the cases from 1998 to 2001 were searched in “China biomedical disk”. The cases of adverse reaction of lincomycin abroad from 1960 to 2001 were searched in the database of MEDLINE. RESULTS: There were 164 patients of adverse reactions of lincomycin in China from 1960 to 2001, and the kind of the most common cases was shock like reaction, which was associated with overdose. There were 772 patients of adverse reactions of lincomycin abroad from 1960 to 2001, and the kind of the most common cases was pseudomembrnous colitis, which was associated with too long time of administration. The shock like reaction was the main reason caused the dying in our country and the pseudomembranous colitis was the main reason caused the dying abroad. CONCLUSION:There is difference in the adverse reaction of lincomycin between home and abroad. Shock like reaction is the most common in our country, which is associated with over dose administration, and this should be attached importance to the clinic.更多还原