【摘要】 目的 :分析我院神经外科监护室 (NICU)呼吸机相关肺炎 (VAP)致病菌分布及其耐药情况 ,为临床抗感染治疗提供实验室依据。方法 :对我院NICU1999年1月～2002年12月69例次VAP的病原菌及耐药性进行回顾分析。结果 :共培养65株细菌 ,其中G—杆菌47株 ,占72 3% ,以铜绿假单胞菌为主 (40 4 % ) ;G +菌18株 ,占27 7 % ,其中金黄色葡萄球菌占77 8 % ,耐甲氧西林金葡菌 (MRSA)占金葡萄中的78 6 %。革兰阴性菌对亚胺培南和头孢吡肟耐药率最低 ,MRSA对万古霉素敏感 ,无1例耐药。结论 :NICU中VAP致病菌以G- 菌为主 ,G+菌亦有增加 ,且多为MRSA。NICU中VAP致病菌耐药普遍 ,细菌学调查对于早期治疗经验性抗感染药物的选择意义重大更多还原

【Abstract】 Objective:To study the bacterial distribution and drug resista nce of ventilator-associated pneumonia in NICUand to determine the treament strategies.Methods:Retrospective analysis was performed on bacterial culture,antibiotics sensivity results in69patients with ventiˉlator-associated pneumonia in NICU.Results:In65strains:gram-positive in47strains(72.3%)and gram-negative in18strains(27.7%).The causative pathogens of VAP were pseudomonas aeruginosa(19strains)and staphylococcus aureus(14strains).Methicillin resistant strains accounted for78.6%of S.gram-negative bacteria were susceptible to imipenem and cefepime.No MRSA was resistant to vanˉcomycin.Conclusion:VAP is caused predominantly by gram-negative bacteria.but gram-positive bacteria also markedly.Bacteriological invesˉtigate plays an important role to select rational antibiotics to early treament of VAP.更多还原