【摘要】 目的:了解深圳地区艾滋病患者的临床流行病学及并发症发生情况,HIV抗病毒及IL-2免疫重建治疗的效果。方法:25例AIDS患者的临床流行病学及并发症,高效抗逆转录病毒治疗(HAART)及IL-2免疫重建治疗进行回顾性分析。结果:艾滋病患者并发症发生部位多系统受累者达88%,机会性感染占所有并发症的68.5%。并发症依次为细菌性肺炎、消化道真菌感染、性病、结核杆菌感染、疱疹病毒感染、肺孢子虫肺炎、皮肤粘膜损害及全血细胞减少等。HIV主要感染途径为性接触占80%,而吸毒途径的为20%。艾滋病患者血红蛋白(Hb)含量的高低对其预后及存活率的判断有重要意义。Hb>8g/dl的艾滋病患者其存活率远高于Hb<8g/dl者。用HAART治疗的艾滋病患者其存活率为81.3%,经HAART治疗一月后,CD4+细胞数目及CD4+/CD8+比值均明显升高。对少数患者使用小剂量IL-2进行免疫重建治疗,可明显减少艾滋病患者的并发症,并提高CD4+水平。结论:艾滋病患者临床表现多样,但并发症仍以机会性感染为主,故临床治疗应以HAART及控制机会性感染治疗为主,建议同时辅以免疫重建治疗,可明显提高生存率及生活质量。更多还原

【Abstract】 Objective:To investigate the clinical epidemiology and complications of AIDS patients in Shenzhen. To evaluate the effectiveness of anti-HIV therapy and immune reconstitution with IL-2. Mehtods:A total of 25 AIDS subjects was analyzed in Shenzhen East Lake Hospital during 11 months in 1997-2002. The retrospective analysis was carried out to study the clinical epidemiology, complications, highly active antiretroviral therapy (HAART) and immune system restoration with IL-2. Results:1. The cases associated with multi-systematic complications were up to 88%. Out of all the complications, the opportunistic infection accounted for 68.5%. The complications in priority were reported to be bacterial pneumonia, fungi infection of alimentary tract, sexual diseases, bacilli tuberculosis, herpes, pneumocysis carinii pneumonia(PCP), mucocutaneous lesion and blood cell decrease. 2. As much as 80%of the infection of HIV is related with sexual contact while 20% with drug abuse. 3. The HB level was extremely crucial for the judgement of prognosis and mortality. The survival rate among patients with Hb>8g/dl is much higer than those with Hb<8g/dl. 4. The survival rate among patients taking HAART treatment is up to 81.3%. One month after HAART treatment, a big increase of CD4(+) cell counts and CD4(+)/CD8(+) ratio was observed. 5. For fewer individuals treated with immune reconstitution at a small dosage of IL-2, the complications significantly decreased and CD4(+) level increased.Conclusion:The clinical manifestations of AIDS patients appeared to be various. The complications were revealed to be mainly opportunistic infection. As a result, a treatment with both HAART and opportunistic infection control should be mainly carried out with the supplement of immune system reconstitution in order to improve survival rate and life quality.更多还原