【摘要】 目的:观察介入栓塞治疗对Graves病T淋巴细胞亚群的影响。方法:24例难治性Graves病,选择性行双侧甲状腺上、下动脉插管,并注入聚乙烯醇或（和）明胶海棉栓塞治疗,观察栓塞后3月T淋巴细胞亚群变化。结果:Graves病患者治疗前CD₃⁺,CD₄⁺与正常组比较差异无显著性（P>0.05）;CD₈⁺下降、CD₄⁺/CD₈⁺比值升高与正常组比较差异有显著性（P<0.05）;介入栓塞治疗后CD₃⁺升高、CD₄⁺下降,CD₈⁺升高,CD₄⁺/CD₈⁺下降与治疗前比较差异有显著性（P<0.05）。结论:介入栓塞治疗可引起Graves病患者T淋巴细胞亚群变化,纠正甲亢免疫调节紊乱,有利于甲亢的治愈。更多还原

【Abstract】 Objective:To observe the influence of interventional embolization treatment on T lymphocyte subpopulation of Graves disease. Methods:Selective arteriography and interentional embolization of thyroid superior and inferior arteries were performed by polyvinyl alcohol or/and gelatin sponge embolization in 24 patients with refractory Graves disease. T lymphocyte subpopulation change was observed after 3 months treatment. Results: There was no significant difference on CD₃⁺ and CD₄⁺ between Graves disease patients and normal group （P >0.05）. CD₈⁺ decreased and the ratio of CD₄⁺ /CD₈⁺ increased in Graves disease patients, there was obvious difference between the Graves group and the normal group （P<0.05） .There was significant difference after the treatment （P>0.05）.CD₃⁺ increased,CD₄⁺ decreased,CD₈⁺ increased and CD4+/CD8+ decreased after the treatment with interventional embolization. Conclusion:Treatment with interventional embolization could cause the change of T lymphocyte subpopulation of Graves disease patients. It could correct the disturbance of immunity in hyperthyroidism, so it was good for the recovery of hyperthyroidism. Further exploration was need to study the mechanism.更多还原