【摘要】 目的:研究芳香化浊方(FH)对急性心肌缺血-再灌注损伤的作用机制。方法:利用结扎冠状动脉左前降支的方法造成大鼠急性心肌缺血-再灌注损伤,对模型大鼠血中肌酸磷酸激酶(CK)、血管内皮素(ET)、白细胞介素-6(IL-6)及肿瘤坏死因子(TNF-α)进行观测。结果:中药能明显降低CK、ET、TNF-α及IL-6的含量,与模型组比较均有统计学差异(P<0.05)。结论:芳香化浊方对大鼠心肌缺血-再灌注损伤的保护作用可能与影响中性粒细胞浸润相关。更多还原

【Abstract】 Objective:To study treating mechanism of Fangxianghuazhuo (FH) on rat MIRI. Methods: The rat MIRI were established by infused for 30 minutes into the left anterior descending coronaryartery, and reperfusion after 45 minutes, then CK, ET, IL-6 and TNF-α were observed. Result:The CK, ET, IL-6, TNF-α were reduced obviously. There is significantly statically difference (P<0.05). Conclusion:The function of Fangxianghuazhou is gradually related to the PMN.更多还原