【摘要】 目的:研究下瘀血汤对实验性肝硬化的防治作用及对脂质过氧化反应的干预作用。方法:将SD大鼠分成中药组、西药组、对照组、正常组。在CCl4+乙醇诱导SD大鼠发生肝硬化的过程中,中药组用下瘀血汤2g/100g体重每日灌胃,西药组每日以秋水仙碱灌胃,剂量为0.01mg/100g体重,对照组按上述方法造模不给药物,正常组不造模正常饲养。结果:中药组大鼠死亡率明显低于对照组和西药组(P<0.05),体重明显高于对照组、西药组(P<0.05);血γ-GT中药组低于对照组(P<0.05),而中药组、西药组间无差异,ALT值中药组低于西药组、对照组(P<0.05,P<0.001),白蛋白含量中药组接近正常组,高于西药组、对照组(P<0.05,P<0.001); 血Ⅳ-C、HA含量中药组、西药组无差异,但中药组明显低于对照组(P<0.05)。中药组GSH-PX水平高于对照组(P<0.001),而LPO值低于对照组(P<0.05),中西药组间GSH-PX存在差异,中药组高于西药组(P<0.05),而在LPO值方面,中西药组间无差异;中药组肝脏大体观基本同西药组,显微观察病理改变状况同西药组相似,但脂变坏死轻,肝硬化的形成情况明显低于对照组(P<0.05)。结论:下瘀血汤对实验性肝硬化的形成具有干预作用,能抗肝纤维化、防治肝硬化,对脂质过氧化反应具有抑制作用,提示下瘀血汤干预脂质过氧化反应作用是其防止肝硬化机?更多还原

【Abstract】 Objective:To investigate the prevention and treatment of Decoction for Removing Blood Stasis (DRBS) on experimental heptic cirrhosis and it’s suppressive effect on lipid peroxidation. Method:The SD rats were allocated to the trational Chinese medicine (TCM) group, the western medicine (WM) group, the control group and the normal group. During the process of inducing the hepatocirrphosis by CCl4 and alcohol in SD rats, the TCM group received DRBS 2g/100g weight/day, the WM group received the colchicine 0.01mg/100g weight/day, the control group was created into the animal model by the above means without treatment, the normal group normally raised without being created into model. Result:The death rate of the TCM group was significantly lower than that of the WM group(P<0.05). The weight of the TCM group was obviously higher than that of the normal group(P<0.05). Compared with the control group, the TCM group’s content of γ-GT in the blood decreased(P<0.05), but there is no difference between the TCM group and the WM group. ALT content of the TCM group was lower than that of the WM group(P<0.05, P<0.001). Albumin content of the TCM group is near to that of the normal group, higher than that of the WM group(P<0.05, P<0.001). There is no difference between the TCM group and the WM group in the contents of IV-C, HA in the blood, but the TCM group was apparently less than that of the control group(P<0.05). GSH-PX level of the TCM group was higher than that of the control group(P<0.001), but LPO content was lower(P<0.05). The TCM group and the WM group existed the difference in GSH-PX level. The former is higher than the latter(P<0.05), but in terms of LPO content, The TCM group and the WM group didn’t exist the difference. The TCM group is similar to the WM group in the chang of liver in normal observation and the pathological change under microscope, but fatty degeneration abated. The degree of hepatic cirrhosis was significantly lower than that of the control group(P<0.05). Conclusion:DRBS has a suppressive effect on hepatocirrhoic development and an action for the prevention and cure of hepatic fibrosis and hepatocirrhosis and an inhibition on lipid peroxidation. It suggests that the action that DRBS intervent in lipid peroxidation is one of anti-hepatocirrhosis mechanisms.更多还原