【摘要】 利用我们研制的基因信息融合分析软件GeneHub,按染色体开窗的方法将人类基因组沿着染色体划分为一系列基因群,用不同的相关测度(Pearson相关、Spearman秩相关、欧氏距离)考察这些基因群中所有基因间在二套独立的基因表达谱数据中的平均表达相关性。实验结果表明,与随机基因群相比,染色体上的邻近基因具有显著的表达相关性。约有40％的被检测基因包含于我们检测到的邻近相似表达基因群中。该现象提示真核生物中的基因存在模块化的共表达趋势。更多还原

【Abstract】 Human genes are positioned along the chromosomes. Average measures of expression correlation were calculated within each group for two independent gene expression dstasets.The results show about 40% of the tested gene sets were contained in the groups of adjacent coexpressed genes.The correlation between the adjacent genes on chromosomes are significantly higher than what in random gene groups. Our results suggest that genes are modularized to express in eukaryote.更多还原