【摘要】 目的 :应用二维超声心动图 (2DE)对接受经皮冠状动脉介入治疗 (PCI)的患者术前、术后 8周 2DE各指标进行观测并与正常组比较 ,以探讨PCI对心梗患者左室重构的影响。方法 :将 2 6例接受PCI术的心梗患者作为研究组 ,另取 2 0例无心脏疾患者为对照组。PCI组分别于术前 1周内、术后 8周完成各指标的测量 ,将PCI术前与术后 8周及正常组的 2DE各指标进行分析 ,以评估PCI对左室重构的影响。结果 :心梗患者术前 2DE指标左室射血分数、小轴缩短率明显低于正常组 (P <0 0 1) ,舒末内径、舒末容量、缩末容量、左室重量指数较正常组明显升高 (P <0 0 1或P <0 0 5 ) ,术后 8周与术前比较左室射血分数 ,小轴缩短率、左室舒末内径、左室重量指数各指标均有不同程度改善 ,但尚无统计学差异 ,缩末容量、舒末容量较术前降低 (P <0 0 5 )。结论 :PCI术可终止或改善缺血与收缩、舒张功能障碍互为因果的恶性循环 ,阻抑或延缓梗塞后的心室重构 ,促进冬眠心肌的恢复。更多还原

【Abstract】 Objective:2-Dimensional Echocardiography (2DE) was used to observe the indexes changes in patients with myocardial infarction before and eight weeks after percutaneous coronary intervention and to explore the impact of PCI on left ventricular remodeling generated as a result of myocardial infarction.Methods:Twenty six patients who received percutaneous coronary intervention were enrolled in this study as PCI group(PCI) and twenty subjects without heart disease as normal control group(NC).The measurements of indexes were respectively completed one week before and eight weeks after PCI in PCI group,the corresponding indexes were also completed in NC group at certain time.By comparing the 2DE indexes derived from mycocardial infarction patients one week before and eight weeks after PCI and from normal controls,the impact of PCI on left ventricular remodeling was assessed.Results:2DE indexes LVEF,△D% were lower and LVDD,ESV,EDV,LVMI were higher in infarction group than that in NC group (P<0.01 or P<0.05);and the indexes LVEF,△D%,LVMI eight weeks after PCI improved but no significant difference was found;however ESV,EDV was significantly lower than before PCI(P<0.05).Conclusion:PCI can stop or improve vicious circle elicited by reciprocal action between ischemia and systolic/diastolic dysfunction,terminate or slow remodeling and promote recovering of hibernating myocardium and therefore is a prosperous method for CHD treatment.更多还原