【摘要】 目的 :研究缬沙坦对原发性高血压患者血管内皮依赖性舒张功能的影响。 方法 :采用高分辨率超声技术对 30例原发性高血压患者服用缬沙坦前后和 30例正常对照者的血管内皮依赖性舒张功能进行检测。 结果 :缬沙坦治疗组肱动脉内皮依赖性舒张较正常对照组明显减弱 (t=2 .4 2 2 ,P <0 .0 5 ) ,30例轻、中度高血压患者服用缬沙坦 12周后 ,收缩压、舒张压均较治疗前明显降低 (t分别为 2 .13、2 .2 1,P均 <0 .0 5 ) ,同时肱动脉内皮依赖性舒张较治疗前明显改善 (t=2 .371,P <0 .0 5 )。 结论 :轻、中度原发性高血压患者存在血管内皮依赖性舒张功能障碍 ,缬沙坦在降压的同时可有效改善其血管内皮依赖性舒张的功能。更多还原

【Abstract】 Objective: To investigate the effect of valsartan on blood pressure and endothelium dependent relaxing function in patients with essential hypertension (EH). Methods: With high resolution ultrasound, we measured endothelium dependent relaxing function in 30 patients with EH who were treated with valsartan and 30 normal persons. Results: In patients with EH, flow mediated dilatation in arteries was much reduced compared with control group (6.7%±3.3% VS 13.3%±3.8%, P<0.05 ), after 30 patients with EH had been treated with valsartan for 12 weeks, their flow mediated vasodilations were greater than before (10.5%±3.9% VS 6.7%±3.3%, P<0.05 ). Conclusion: Endothelium dependent vasodilation was impaired in patients with EH, and hypertension management with valsartan may improve endothelium dependent vasodilation function.更多还原