【摘要】 目的 :了解血管紧张素转换酶 (ACE)基因多态性与新疆地区原发性高血压的易感相关性。方法:应用聚合酶链反应 (PCR)对 78例新疆地区原发性高血压患者与 72例正常血压对照者 ACE基因第 16内含子插入 /缺失多态性进行鉴定。结果:在新疆地区原发性高血压患者中 ,ACE基因缺失纯合基因型 (DD)和缺失 (D)等位基因频率均明显高于正常血压者 (P <0 .0 5及 P <0 .0 1)。结论:ACE基因缺失纯合型可能是新疆地区原发性高血压遗传易感因素之一更多还原

【Abstract】 Objective: To asses whether the insertion/deletion(I/D) polymorphism of angiotensin coverting enzyme (ACE) gene was associated with essential hypertension in xinjiang. Methods: I/D polymorphism of ACE was determined by polymerase chain reaction (PCR) in 72 normal controls, 78 patients with essential hypertension. Results: The frequencies of DD gene type (0.30) and deletion allele (0.53) among essential hypertension were significantly higher than those (0.14) among control subjects (0.375). Conclusion: The results indicate that a deletion polymorphism of ACE gene probably may be the risk factor in essential hypertension in xinjiang.更多还原