【摘要】 [目的]观察进展期胃癌术前介入化疗的临床疗效和病理变化。[方法]对65例进展期胃癌患者进行术前动脉介入化疗,采用Seldinger技术,根据癌灶部位选择性动脉插管,方案为:5鄄Fu750mg/m2,MMC10mg/m2,DDP60mg/m2。化疗后7~10天手术,对术后胃标本进行组织病理学检查,同时观察术后生存率。[结果]65例均获手术切除,组织病理学改变总有效率70%,术后1年和2年生存率分别为96.92%和89.23%。[结论]术前介入化疗有助于提高手术切除率和术后生存率,且并发症较少,可作为进展期胃癌的术前常规辅助化疗方法。更多还原

【Abstract】 To evaluate the efficacy of pre-operative transcatheter arterial chemotherapy(TAC)for advanced gastric cancer(AGC).Sixty-five cases of AGC underwent TAC by Seldinger technique.The anticancer drugs used were5-Fu750mg/m 2 ,MMC10mg/m 2 ,DDP60mg/m 2 .All patients were performed operation7~10days post-TAC.Histopathological changes were studied in all specimens.Ten specimens were studied by electronic microscopy.Tumor had been resected completely in65cases.The overall histopathologically response rates was70%.The1-and2-year survival rates were96.92%and89.23%,respectively.[Conclusions]Preoperative TAC is benefit to tumor resected rate and survival rate with less complication.It may be as a preoperative routine adjuvant chemotherapy for advanced gastric cancer.更多还原