【摘要】 目的　探讨拉米夫定 (贺普丁 )治疗慢性重型乙型肝炎的疗效。方法　 4 8例患者 ,男性 ,2 7～ 5 6岁 ,临床诊断为慢性重型乙型肝炎 ,随机分为二组。治疗组在综合治疗基础上口服贺普丁片 0 .1,qd ,对照组除不用贺普丁余同治疗组 ,三个月后分别观察肝功能、HBV M和HBV DNA等变化。结果　治疗组在改善肝功能及HBeAg和HBV DNA阴转率及提高存活率诸方面较对照组有显著性差异。结论　贺普丁治疗慢性重型乙型肝炎对提高存活率有一定意义 ,未见明显不良反应更多还原

【Abstract】 OBJECTIVE To study the effect of lamivudine in the treatment of chronic fulminant hepatitis B. METHOD 48 patients with the diagnosis of chronic fulminant hepatitis B (aged 27 56)were randomly divided into 2 groups. One group was given lamivudine 0.1g/d, based on other conclusive treatment, while the control group was given the same treatment but without lamivudine. The patients’ liver function,HBV M,HBV DNA were investigated after treatment for 3 months.RESULTS Significant differences were found between the 2 groups in the liver function change, HBeAg and HBV DNA loss or seroconversion and the survival rate.CONCLUSION Lamivudine may increase the survival rate of chronic fulminant hepatitise and no side effect was found.更多还原