【摘要】 目的　探讨影响中晚期肝细胞肝癌手术切除预后的因素。　方法　对 13 0例中晚期大肝癌随访 1～ 7年 ,采用单因素、多因素分析统计不同预后因素对患者生存率的影响。　结果　手术后 1,3 ,5年生存率分别为 81.7% ,2 4.3 % ,18.4%。单因素分析提示影响预后的因素为肝癌大小、是否早期复发、肝硬化情况、输血量 ;多因素分析提示肝癌大小、肿瘤早期复发是影响肝癌术后的预后因素。　结论　中晚期肝癌手术切除预后仍不理想 ,重视围手术期处理 ,预防术后早期复发有望提高手术疗效更多还原

【Abstract】 Objective To study the prognostic factors in patients who received hepatectomy for large hepatocellular carcinoma(HCC). Methods 130 patients operated for large HCC were followed up for 1～7 years. Twenty possible factors were analyzed by Kaplan-Meier Log rank estimate. A multivariative survival analysis of these individal variable was undertaken using the cumulative survival rate by the computers COX proportional hazard. Result The overall cumulative survival rate at 1,3,5 years was 81.7%,24.3%,18.4% respectively.The size of tumor,time of recurrence of the tumor,status of liver cirrhosis,amount of blood infusion were the factors which affected the prognosis of the patients in single-variative analysis;while multi-variative survival analysis showed that the size of the tumor and the time of recurrence of the tumor were the main factors which affected the prognosis of the patients. Conclusion Prognosis of the patients with large HCC is poor. Control of early recurrence of HCC may improve the prognosis of HCC patients.更多还原