【摘要】 目的　调查职业接触化疗药物及接触时间对护士肝脏转氨酶的影响 ,了解职业接触化疗药物危害性。方法　分析我院 1 92名接触化疗药物健康护理人员的肝脏转氨酶 (谷丙转氨酶、谷草转氨酶 )改变 ,将接触化疗药物的时间分为 0年、1～ 5年、6～ 1 0年、>1 0年 4组 ,其相应的人数分别是 2 2名、52名、88名、30名 ,计算出各组转氨酶活性异常的比例 ,比较各组之间的差异。结果　转氨酶活性异常的比例分别是 :0年 4 .5 %、1～ 5年 9.6 %、6～ 1 0年 2 1 .6 %、>1 0年 2 3 .3 % ,各组之间的比例有差异 (χ2 =1 3 .1 7,P <0 .0 1 ) ;总异常比率为 1 6 .7%。结论　职业接触化疗药物对护理人员肝脏转氨酶有影响 ,接触时间越长 ,肝脏转氨酶活性异常的比率越大更多还原

【Abstract】 Objective To investigate the influence of vocational contact with chemotherapeutic agents on nurses’ hepatic function and health. Methods Data of aminotransferase (ALT, AST) of 192 nurses in our hospital who contacted constantly with varieties of chemotherapeutic agents were collected. According to their medicine contact periods, 192 nurses were divided into 4 groups (0 year, 1 to 5 years, 6 to 10 years, and over 10 years). The number of each group was 22, 52, 88 and 30 respectively. The ratio of nurses with abnormal aminotransferase level of each group was calculated and compared. Results The ratios of nurses with abnormal aminotransferase level of each group was 4.5%, 9.6%, 21.6% and 23.3% respectively. The overall ratio of abnormal aminotransferase level in 192 nurses was 16.7%. These was significant difference of abnormal aminotransferase ratio among these groups (χ 2=13.17, P <0.01). Conclusion This investigation suggested that vocational contact with chemotherapeutic agents could influence nurses’ hepatic function, the longer their medicine contact period, the higher ratio of nurses with abnormal aminotransferase level.更多还原