【摘要】 目的通过检测运动后大鼠血清心肌肌钙蛋白I(cTnI)和磷酸肌酸激酶(CK),磷酸肌酸激酶同工酶(CK-MB),乳酸脱氢酶(LDH)并将它们进行比较,以期探讨它们在运动医学中的应用价值。方法38只SD大鼠分为对照组,游泳力竭后即刻组,游泳4.5h后6h,18h,24h组,分别测定其血清cTnI,CK,CK-MB,LDH。cTnI检测用改良Bodor双抗夹心酶联免疫法。CK-MB测定用免疫抑制法。结果①游泳力竭后即刻组,大负荷运动后6,18,24h组cTnI的OD值与对照组相比,t=1.567,ν=13,P=0.141;F=1.393,P=0.267,组间P值0.061～0.897,显示差异均无显著性。②游泳力竭后即刻组CK,CK-MB,LDH升高,与对照组相比,t值分别为4.027,10.666,9.413,P值均<0.01,差异有显著性。③大负荷运动后6h组CK,CK-MB,LDH升高,与对照组相比,P值分别是0.044,0.015,0.019,P值均<0.05,差异有显著性。结论①游泳力竭后即刻CK,CK-MB,LDH升高,但cTnI未有升高,尚需进一步动态检测cTnI。②大负荷运动后,动态检测未见有血清cTnI升高,提示未有心肌损伤。③大负荷运动后6h组出现的CK,CK-MB,LDH升高是否表明有心肌损伤应重新认识。更多还原

【Abstract】 Aim To explore the influence of dyslipidemia on early renal function al lesions in patients with metabolic syndrome(MS).Methods 109 cases with essentia l hypertension (56 males and 53 females, EH group), 73 cases with diabetes melli tus (39 males and 34 females, DM group) and 175 cases with metabolic syndrome (8 7 males and 88 females, MS group) were respectively divided into two subgroups: normal lipid groups and dyslipidemia groups according to the serum total cholest erol(TC), triglycerides(TG), low density lipoprotein(LDL), and apolipoprotein B( Apo B) levels. The changes of renal function were observed and comparde between the subgroups of normal and dyslipidemia respectively.Results In the MS group, t he concentration of microalbuminuria(MA) in the dyslipidemia group was(66±3) mg within 24 hours, significantly higher than that of the normal group [(45±4)mg, t=-3.904,P< 0.01]; the endogenous creatinine clearance rate (Ccr) was (57±3) m L/min in the dyslipidemia group, significantly lower than that in the normal gro up[(72±4)mL/min,t=-3.838,P< 0.01].But in the DM and EH groups,the concentratio ns of MA and Ccr were insignificantly different between the normal and dyslipide mia groups respectively. The correlation analysis showed that TC, LDL and ApoB o nly in the MS group were significantly related with MA and Ccr, and the TC playe d a most important role in MA and Ccr(r=0.3807,P< 0.01;r=0.3807,P< 0.05).Conc lusion Dyslipidemia is one of the important factors inducing renal dysfunction i n patients with MS when blood pressure and glucose are controlled at the same le vels. Thus, serum lipid lowering therapy may be necessary to prevent deteriorati on of renal function in patients with metabolic syndrome.更多还原