【摘要】 目的通过生育年龄吸毒女性及自愿受检非吸毒正常女性,从下丘脑生殖轴、外周血女性相关激素水平及临床症状体征3个水平进行对比研究,以探讨长期使用海洛因对女性生殖系统的损害。方法填写调查表、对患者进行相关体检,抽血进行女性激素检测、阴道细胞涂片查雌激素影响程度或卵巢功能低下情况、妇科彩色B超测量子宫及其内膜和卵巢大小。结果吸毒组促性腺激素释放激素(GnRH)、雌二醇(E2)、孕酮(P)明显低于正常组,而卵泡刺激素(FSH)、黄体生成素(LH)相反明显高于正常组(P<0.01及<0.05);与正常组比,吸毒组阴道雌激素水平降低、而阴道pH值升高(P<0.05);皮下脂肪减少、子宫、子宫内膜、卵巢、乳房、脂肪、大阴唇等明显萎缩(P<0.05或P<0.01);另吸毒组多数显现月经紊乱、停经或闭经。结论长期使用海洛因可通过抑制生殖轴、抑制排卵及卵巢功能等途径,对女性生殖系统造成明显损害。长期吸毒可致卵巢功能减退甚至衰竭危险。更多还原

【Abstract】 Aim To study the effects of heroin on fema le reproductive system.Methods To fill in the investigation list,ch eck the patients,draw blood to determine female hormone,t est the level of Estrogen effect by th at vaginal cells were painted glass-pl ates,check the uterus and ovarium by color Doppler ultrasonography.Results In female heroin addicts group,the l evel of GnRH,E 2 ,P and the Estrogen effect level of vaginal cells were lower than that in normal group,and FSH,LH,PH o f vaginal were higher than that in normal group;Uterus,endometrium,breasts,fat and labium major had shrivled.Menstruation was disorder or stop.Conclusions Using heroin longer can depress or inhibit ovulation,ov ary function,hypothalam-ic-hypophyseal-ovarian axis,and l ead to impair of female reproductive system.更多还原