【摘要】 在不对称催化氢化过程中起关键作用的是手性催化剂的结构,包括手性膦配体和中心过渡金属。简介了手性膦配体的过渡金属络合物的发展历程,即从单膦配体到双膦配体,从P-手性配体到C-手性配体,从双膦铑(Ⅰ)催化剂到双膦-钌(Ⅱ)催化剂;综述了各种新型手性配体催化剂在不同不对称催化氢化(包括C=C、C=O、C=N双键)中的应用,并对其最新进展及研究方向进行了探讨。更多还原

【Abstract】 Induced by a small amount of chiral catalysts, H₂ is added to the unsaturated double bond, and the chiralmolecule is efficiently obtained in this catalytic asymmetric hydrogenation. The construction of the chiral catalyst, which includeschiral phosphine ligand and central transition-metal, plays an important role in the process of catalysis. At present, using transi-tion-metal complex compound of chiral phosphine ligand as a catalyst in the asymmetric hydrogenation reaction is one of themost remarkable fields in the asymmetric catalytic research. The development of transition-metal complex compound of chiralphosphine ligand, which is from single ligand to multi-ligand, from p-chiral ligand to C-chiral ligand, from rhodium（Ⅰ）-diphos-phine ligand catalyst to ruthenium（Ⅱ）-diphosphine ligand catalyst, is introduced. The application of new chiral catalyzers in thecatalytic asymmetric hydrogenation of various unsaturated prochiral substrates containing C=Z（Z=C, N, O） double bond is alsoreviewed. New progress and researeh direction in this area are also discussed.更多还原