【摘要】 目的　探讨血瘀证模型大鼠血浆血栓烷B2 (TXB2 )、6 酮 前列腺素F1α(6 Keto PGF1α)的水平与肿瘤肝转移的关系。方法　用地塞米松和肾上腺素法复制血瘀证模型 ,对照组则给予等量生理盐水。血瘀证模型复制成功的次日 ,两组大鼠均经脾接种W 2 56肉瘤株制作肿瘤肝转移模型。观察两组肿瘤的生长情况、肝转移灶的数目 ,并用放免法测定血浆TXB2 和 6 Keto PGF1α的浓度。结果　血瘀证组原发灶的肿瘤重量与肝转移灶的数目明显少于对照组 ,有显著性差异 ;而血浆 6 Keto PGF1α、TXB2 及TXB2 /6 Keto PGF1α均高于对照组 ,有显著性差异。结论　机体在血瘀状态下 ,其原发肿瘤生长较慢 ;血浆 6 Keto PGF1α和TXB2 均有所升高 ,而肿瘤转移的发生率未见明显增加更多还原

【Abstract】 ObjectiveTo observe the correlation between serum level of TXB 2,6-Keto-PGF 1α and liver metastasis. Methods WT BZThe metastatic model was made by injection of W256 carcinosarcoma. Rats wer e randomly divided into two groups: rats with blood stasis group and control gro up. Rats in control group were given normal saline via abdominal cavity once a day. Rats in blood stasis group were injected adrenalin in the fourteenth day . Tumor size and liver metastasis were observed. Serum TXB 2 and 6-Keto-PGF 1α were tested by radioimmunoassay. ResultsTumor size in rat s with blood stasis was significantly smaller than that of the control group( P <0.01). Occurrence of liver metastasis in rats with blood stasis was signif icantly lower than that of the control group(P <0.01). The values of 6-Ke to-PGF 1α ,TXB 2,and TXB 2/6-Keto-PGF 1α were higher in the gr oup with blood stasis. ConclusionIn the status of blood stasis,W 256 carcinosarcoma grows slowly,and liver metastasis increases insignificantly ,with the elevations of 6-Keto-PGF 1α ,TXB 2 and TXB 2/6-Keto-PGF 1α .更多还原