【摘要】 功能基因组学是在结构基因组学丰富信息资源的基础上 ,应用大通量的实验分析方法并结合统计和计算机分析研究基因的表达、调控与功能以及生物的生长、发育规律的新型交叉学科。基因功能研究采用从基因到表型和从表型到基因两种策略 ,使用多种方法创造大量变异及大通量识别并克隆基因和研究基因表达模式的技术。如基因陷阱、基于差异杂交的基因表达差异研究技术、 DNA芯片和蛋白质芯片等。随着研究技术不断改进和创新 ,功能基因组研究将成为生命科学研究的重点和热点。更多还原

【Abstract】 Functional genomics refers to the development and application of global experimental approaches to assess gene function, gene expression profile, organism growth, development and metabolic regulation by making use of the information and reagents provided by structural genomics. It is characterized by high throughput experimental methodologies combined with statistical and computational analysis of the results. The fundamental strategies in investigation of gene function are from phenotype to gene and from gene to phenotype. Many large-scale experimental methods are used to induce mutation, identify and clone gene. For example: gene trap, studying methods of differential hybidrization-based gene expression, DNA chips, protein chips, etc. With advance of improvement and innovation of methodology, we believe that functional genomics will become the hot spot in the field of life science.更多还原