【摘要】 目的 :探讨血清及尿液中血管抑素含量与膀胱移行细胞癌发展、转移、疗效及预后的关系。方法 :采用赖氨酸 -酶联免疫吸附分析 (Lysine -ELISA)法检测 6 9例膀胱移行细胞癌患者治疗前血清及尿液中血管抑素 (angiostatin)的水平 ,以及治疗后血清中血管抑素的水平。结果 :膀胱移行细胞癌患者治疗前血清及尿液中血管抑素的水平明显高于正常对照组 (P <0 .0 1) ,并与肿瘤大小、临床分期、分级及有无远处转移密切相关。膀胱移行细胞癌患者治疗后 2 4h血清中血管抑素的水平并无显著降低 (P >0 .0 5 ) ,治疗后 1周血管抑素水平明显降低 ,与治疗前差异显著 (P <0 .0 1)。结论 :膀胱移行细胞癌患者血清和尿液中血管抑素的水平在一定程度上可以反应膀胱移行细胞癌的发展及治疗情况。更多还原

【Abstract】 Objective: To investigate the relationship between angiostatin and the development, metastasis,curative effect and prognosis of bladder transitional cell carcinoma. Methods:The serum and urine angiostatin level in 69 patients with bladder transitional cell carcinoma were determined by Lysine-ELISA method before and after treatment.Results:The angiostatin level in serum and urine of patients with bladder transitional cell carcinoma prior to treatment were significantly higher than that in control group(P<0.01), and correlated with tumor diameter, clinical grades ,stages, metastasis and curative effect.There was no significant differece in angiostatin level between prior and 24 h after treatment(P>0.05). The angiostatin level in serum and urine 7 days after treatment were significantly lower than that prior to treatment(P<0.01),but there was no significant difference with control group (P>0.05).Conclusion:[WT5BZ]The serum and urine angiostatin level could be a marker of the clinical stages and metastasis of bladder transitional cell carcinoma and may play a role in the biological character of curative effect and prognosis.更多还原